Synthesis and anti-hypertensive activity of some dihydropyrimidines

1553-1557Wide range of biological activities are associated with 1,4-dihydropyridines/pyrimidines, individually or in combination. In view of the synthesis of various 6-methyl-4 substitutedphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters and 6-methyl-4-substituted phenyl-2-S-alkyl(benzyl)-1,4-dihydropyrimidine-5-carboxylic acid ethyl esters was undertaken for synthesizing biologically active molecules with improved activity, lesser toxicity with undesirable side effects in clinical use. The synthesized compounds have been tested for anti-hypertensive activity and show some new results about the structure-activity relationship contrary to an earlier reports

Micelle based synthesis of cobalt ferrite nanoparticles and its characterization using Fourier transform infrared transmission spectrometry and thermogravimetry

Cobalt ferrite (CoFe2O4) nanoparticles of average size 4 nm with narrow size distribution are synthesized by reverse micelle approach. The nanoparticles are characterized using powder X-ray diffraction (XRD), Dynamic Light Scattering (DLS), Theromogravimetric analysis (TGA) and Fourier Transform Infrared Transmission Spectrometry (FTIR). Three successive transformations are observed in the thermogram that correspond to the loss of solvent and surfactant; onset of the amorphous to crystallize conversion; and isochemical transformation, i.e. migration of cations between octahedral and tetrahedral sites in the inverse spinel structure. The isochemical transformation is further confirmed by FTIR. The IR absorption bands observed at 460 and 615 cm−1 in the as-prepared CoFe2O4 nanoparticles correspond to the ferrite skeleton of octahedral and tetrahedral sites, respectively. The peak intensity at 615 and 460 cm−1 is shifted to 601 and 440 cm−1, respectively upon annealing at 320 and 400°C. These results confirm migration of cations from the octahedral to the tetrahedral sites

A novel oxidative dimerization of acetylenes to conjugated dicarbonyl systems using iron (III) perchlorate

1170-1171<span style="font-size: 12.0pt;font-family:" times="" new="" roman";mso-bidi-language:ar-sa"="">Acetylenes 1a-e, terminal as well as substituted, have been converted into α,<span style="font-size:12.0pt;font-family: Symbol;mso-ascii-font-family:" times="" new="" roman";mso-hansi-font-family:"times="" roman";="" mso-bidi-font-family:"times="" roman";mso-bidi-language:ar-sa;mso-char-type:="" symbol;mso-symbol-font-family:symbol"="">b<span style="font-size:12.0pt; font-family:" times="" new="" roman";mso-bidi-language:ar-sa"="">-unsaturated dicarbonyl systems 2a-e in good to excellent yields when reacted with Iron (III) perchlorate (ITP) using acetonitrile as the solvent. </span